3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016887 | IPR029915 |
| GO:0043044 | IPR029915 |
| GO:0016589 | IPR029915 |
| Type: | Family | Name: | ISWI family |
| Description: | This entry represent the ISWI family. Its members include ISWI from fruit flies and SMCA1/SMCA5 (SNF2L/SNF2H) from mammals. ISWI is part of the NURF complex, which is an ATP-dependent chromatin remodeling complex that regulates transcription by catalysing nucleosome sliding []. Its structure has been solved []. SMCA5 is a homologue of Drosophila ISWI, which is a major catalytic ATPase subunit of several ISWI-type chromatin remodeling complexes [, ]. Its SLIDE domain can associate with UV-damaged chromatin to specifically promote CSB protein recruitment and to resolve damage-stalled transcription []. It can be recruited to DNA double-strand breaks in a poly(ADP-ribose) polymerase 1 (PARP1)-dependent manner []. | Short Name: | ISWI |
| GO Term | Gene Name |
|---|---|
| GO:0016887 | IPR029915 |
| GO:0043044 | IPR029915 |
| GO:0016589 | IPR029915 |
