Protein Domain : IPR008859

Type:  Domain Name:  Thrombospondin, C-terminal
Description:  Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.The globular C-terminal domain is a beta sandwich of two curved antiparallel beta-sheets []. The fold is an elaboration of the jelly role topology, with strand B3-B7, B11 and B14-B15 forming the eight-stranded jelly roll motif. The function of the C-terminal domain is not yet known. Short Name:  Thrombospondin_C
Paste the following link

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF05735
PS51236

1 Found In

DB identifier Type Name
IPR015455 Family Thrombospondin-2

3 GO Annotations

GO Term Gene Name
GO:0005509 IPR008859
GO:0007155 IPR008859
GO:0005576 IPR008859

3 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR008859
GO:0007155 IPR008859
GO:0005576 IPR008859

1 Parent Features

DB identifier Type Name
IPR013320 Domain Concanavalin A-like lectin/glucanase domain

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11687483
            15014436