| Type: | Family | Name: | Uncoordinated protein 13 (Unc-13) |
| Description: | Unc-13 is a phorbol ester/diacylglycerol-binding protein that plays a role in vesicle maturation during exocytosis [, ]. Unc-13 disruption causes diverse defects in the nervous system of the nematode Caenorhabditis elegans [, ]. This family also includes mammalian homologues A, B and C []. Unc13 homologue C is cerebellum-specific and regulates cerebellar synaptic transmission []. Homologues A and B are involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion []. They are essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses []. | Short Name: | Unc-13 |
