Protein Domain : IPR030332

Type:  Family Name:  Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Description:  SERCA1 belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane. SERCA1 is a specialised Ca2+ pump, known as SERCA pump, which is localised in sarcoplasmic reticulum and endoplasmic reticulum []. In humans, SERCA is expressed in fast-twitch skeletal muscle and is alternatively spliced to encode SERCA1a (994 aa, adult) and 1b (1011 aa, foetal). The structure of SERCA1 has been solved [, ]. Mutations in the gene have been linked to the Brody disease, which is a rare skeletal muscle disorder transmitted as an autosomal recessive or dominant trait [, ]. Short Name:  SERCA1
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR24093:SF215
PTHR24093:SF258

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0005388 IPR030332
GO:0005524 IPR030332
GO:0070588 IPR030332
GO:0005783 IPR030332
GO:0016021 IPR030332
GO:0033017 IPR030332

6 Ontology Annotations

GO Term Gene Name
GO:0005388 IPR030332
GO:0005524 IPR030332
GO:0070588 IPR030332
GO:0005783 IPR030332
GO:0016021 IPR030332
GO:0033017 IPR030332

1 Parent Features

DB identifier Type Name
IPR005782 Family P-type ATPase, subfamily IIA, SERCA-type

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17286271
            23911890
            8841193
            12409199