Protein Domain : IPR017353

Type:  Family Name:  Methyl-CpG binding protein MeCP2
Description:  Methyl-CpG-binding protein 2 (Mecp2) binds specifically to methylated DNA and represses transcription through the recruitment of chromatin remodeling complexes containing histone deacetylase activities [, ]. It is a multi-functional protein whose function depends on its protein partners and post-translational modifications []. Mecp2 is required for proper mitotic spindle organisation [] and affects proliferation and apoptosis []. Mutations in MeCP2 gene cause an X-linked neurodevelopmental disease known as Rett syndrome []. Short Name:  Me_CpG-bd_MeCP2
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0 Child Features

1 Contains

DB identifier Type Name
IPR001739 Domain Methyl-CpG DNA binding

1 Cross References

Identifier
PIRSF038006

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0010385 IPR017353
GO:0042826 IPR017353
GO:0000122 IPR017353
GO:0045892 IPR017353
GO:0005634 IPR017353

5 Ontology Annotations

GO Term Gene Name
GO:0010385 IPR017353
GO:0042826 IPR017353
GO:0000122 IPR017353
GO:0045892 IPR017353
GO:0005634 IPR017353

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9620804
            25527496
            9620779
            25165434
            25227661
            11738839