Protein Domain : IPR030330

Type:  Family Name:  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Description:  SERCA3 belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane. SERCA3 is a specialised Ca2+ pump, known as SERCA pump, which is localised in sarcoplasmic reticulum and endoplasmic reticulum []. This entry also includes SERCA3 homologues from insects. There are several alternatively spliced SERCA3 isoforms in humans that are involved in maintaining normal heart function []. In cancer cells, SERCA3 is involved in cell differentiation and tumorigenesis []. Mutations in the human SERCA3 gene are also associated with type 2 diabetes []. Short Name:  SERCA3
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24093:SF280

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0005388 IPR030330
GO:0005524 IPR030330
GO:0070588 IPR030330
GO:0005783 IPR030330
GO:0016021 IPR030330
GO:0033017 IPR030330

6 Ontology Annotations

GO Term Gene Name
GO:0005388 IPR030330
GO:0005524 IPR030330
GO:0070588 IPR030330
GO:0005783 IPR030330
GO:0016021 IPR030330
GO:0033017 IPR030330

1 Parent Features

DB identifier Type Name
IPR005782 Family P-type ATPase, subfamily IIA, SERCA-type

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            19962989
            17286271
            21885870
            23157274