Protein Domain : IPR021169

Type:  Family Name:  Histone H3-K79 methyltransferase, metazoa
Description:  This entry represents a group of histone H3-K79 methyltransferases from insects and vertebrates. They are yeast Dot1 homologues that possess intrinsic H3-K79-specific histone methyltransferase (HMTase) activity []. In Drosophila, it is also known as protein grappa (gpp), which is required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. It is also involved in telomeric silencing, but do not affect centric heterochromatin []. Short Name:  DOT1L/grappa
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0 Child Features

1 Contains

DB identifier Type Name
IPR013110 Domain Histone methylation DOT1

1 Cross References

Identifier
PIRSF037123

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0018024 IPR021169
GO:0006342 IPR021169
GO:0034729 IPR021169
GO:0005634 IPR021169

4 Ontology Annotations

GO Term Gene Name
GO:0018024 IPR021169
GO:0006342 IPR021169
GO:0034729 IPR021169
GO:0005634 IPR021169

1 Parent Features

DB identifier Type Name
IPR030445 Family Histone H3-K79 methyltransferase

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12123582
            15371351