Protein Domain : IPR027258

Type:  Family Name:  Mitogen-activated protein kinase kinase kinase 13
Description:  MAP3K13 (also known as leucine zipper-bearing kinase LZK) activates the c-Jun-NH2 terminal kinase (JNK) pathway through activation of the MAP kinase kinase MAP2K7 [, ]. MAP3K13 acts synergistically with peroxiredoxin-3 (PRDX3) to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B []. MAP3K13 forms dimers/oligomers through its dual leucine zipper-like motif, and that this is necessary for activation of the JNK/SAPK pathway []. Short Name:  MAPKKK13
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR23257:SF336
PIRSF500742

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0004709 IPR027258
GO:0042803 IPR027258
GO:0000186 IPR027258
GO:0007254 IPR027258
GO:0046777 IPR027258
GO:0051092 IPR027258

6 Ontology Annotations

GO Term Gene Name
GO:0004709 IPR027258
GO:0042803 IPR027258
GO:0000186 IPR027258
GO:0007254 IPR027258
GO:0046777 IPR027258
GO:0051092 IPR027258

1 Parent Features

DB identifier Type Name
IPR017419 Family Mitogen-activated protein kinase kinase kinase 12/13

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12492477
            11163770
            11726277