Protein Domain : IPR019779

Type:  Active_site Name:  Galactose-1-phosphate uridyl transferase, class I His-active site
Description:  Galactose-1-phosphate uridyl transferase (galT) catalyses the transfer of an uridyldiphosphate group on galactose (or glucose) 1-phosphate. During the reaction, the uridyl moiety links to a histidine residue. In the Escherichia colienzyme, it has been shown [] that two histidine residues separated by a single proline residue are essential for enzyme activity. The first H binds zinc and the second H is an active site residue. On the basis of sequence similarities, two apparently unrelated families seem to exist. Class-I enzymes are found in eukaryotes as well as some bacteria such as E. coli or Streptomyces lividans, while class-II enzymes have been found so far only in bacteria such as Bacillus subtilisor Lactobacillus helveticus[]. Short Name:  GalP_UDPtransf1_His-AS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00117

3 Found Ins

DB identifier Type Name
IPR011146 Domain HIT-like domain
IPR001937 Family Galactose-1-phosphate uridyl transferase, class I
IPR005849 Domain Galactose-1-phosphate uridyl transferase, N-terminal

3 GO Annotations

GO Term Gene Name
GO:0008108 IPR019779
GO:0008270 IPR019779
GO:0006012 IPR019779

3 Ontology Annotations

GO Term Gene Name
GO:0008108 IPR019779
GO:0008270 IPR019779
GO:0006012 IPR019779

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2066342
            2845364