3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016422 | IPR025848 |
| GO:0001510 | IPR025848 |
| GO:0005634 | IPR025848 |
| Type: | Family | Name: | mRNA (2-O-methyladenosine-N(6)-)-methyltransferase |
| Description: | This family of enzymes methylate adenosine residues of some mRNAs, forming N6-methyladenosine (m6A). m6A, which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation [].Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor. | Short Name: | MT-A70 |
| GO Term | Gene Name |
|---|---|
| GO:0016422 | IPR025848 |
| GO:0001510 | IPR025848 |
| GO:0005634 | IPR025848 |
