4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016567 | IPR030577 |
| GO:0032465 | IPR030577 |
| GO:0035853 | IPR030577 |
| GO:0031463 | IPR030577 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016567 | IPR030577 |
| GO:0032465 | IPR030577 |
| GO:0035853 | IPR030577 |
| GO:0031463 | IPR030577 |
| Type: | Family | Name: | Kelch-like protein 21 |
| Description: | Kelch-like protein 21 (KLHL21) is a substrate adaptor protein in the Cul3-KLHL21 E3 ubiquitin ligase complex. During cytokinesis, it localises to midzone microtubules in anaphase and recruits aurora B and Cul3 to this region [].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form beta-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ]. | Short Name: | KLHL21 |
| GO Term | Gene Name |
|---|---|
| GO:0016567 | IPR030577 |
| GO:0032465 | IPR030577 |
| GO:0035853 | IPR030577 |
| GO:0031463 | IPR030577 |
| GO Term | Gene Name |
|---|---|
| GO:0016567 | IPR030577 |
| GO:0032465 | IPR030577 |
| GO:0035853 | IPR030577 |
| GO:0031463 | IPR030577 |
