Protein Domain : IPR017202

Type:  Family Name:  Sensor histidine kinase LiaS/VraS
Description:  This entry represents signal transduction histidine kinases such as LiaS from Bacillus subtilis and VraS from Staphylococcus aureus. LiaS is a member of the two-component regulatory system LiaS (HK)/LiaR(RR), which is probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin) []. LiaS may also be involved in response to cationic antimicrobial peptides and secretion stress. VraS is a member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. It probably activates VraR by phosphorylation []. Short Name:  LiaS/VraS
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0 Child Features

2 Contains

DB identifier Type Name
IPR003594 Domain Histidine kinase-like ATPase, C-terminal domain
IPR011712 Domain Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain

1 Cross References

Identifier
PIRSF037431

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000155 IPR017202
GO:0004673 IPR017202
GO:0000160 IPR017202
GO:0016021 IPR017202

4 Ontology Annotations

GO Term Gene Name
GO:0000155 IPR017202
GO:0004673 IPR017202
GO:0000160 IPR017202
GO:0016021 IPR017202

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10708580
            17064367