Protein Domain : IPR020848

Type:  Conserved_site Name:  AP endonuclease 1, conserved site
Description:  DNA damaging agents such as the anti-tumour drugs bleomycin and neocarzinostatin or those that generate oxygen radicals produce a variety of lesions in DNA. Amongst these is base-loss which forms apurinic/apyrimidinic (AP) sites or strand breaks with atypical 3' termini. DNA repair at the AP sites is initiated by specific endonuclease cleavage of the phosphodiester backbone. Such endonucleases are also generally capable of removing blocking groups from the 3' terminus of DNA strand breaks.AP endonucleases can be classified into two families based on sequence similarity. This family contains members of AP endonuclease family 1. Except for Rrp1 and arp, these enzymes are proteins of about 300 amino-acid residues. Rrp1 and arp both contain additional and unrelated sequences in their N-terminal section (about 400 residues for Rrp1 and 270 for arp). The proteins contain glutamate which has been shown [] in the Escherichia colienzyme to bind a divalent metal ion such as magnesium or manganese. Short Name:  AP_endonuclease_F1_CS
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PS00727
PS00728

1 Found In

DB identifier Type Name
IPR005135 Domain Endonuclease/exonuclease/phosphatase

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR020848
GO:0004519 IPR020848
GO:0006281 IPR020848
GO:0005622 IPR020848

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR020848
GO:0004519 IPR020848
GO:0006281 IPR020848
GO:0005622 IPR020848

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7885481