| Type: | Family | Name: | Potassium voltage-gated channel subfamily H member 5 |
| Description: | This entry includes the founding member of the voltage-gated potassium channel ether-a-go-go-Eag from Drosophila melanogaster [], and EAG2 (KCNH5, KV10.2) from mammals. Drosophila Eag is a structural component of the potassium channel that can be modulated by the Camguk (CMG)/CASK adaptor protein, and this modulation affects Ether-a-go-go potassium current through a phosphorylation-dependent mechanism []. Human EAG2 is expressed in the brain, but is also found in a range of tissues including skeletal muscle []. In medulloblastoma, it controls mitotic entry and tumour growth via regulating cell volume dynamics []. The voltage-gated potassium channel ether-a-go-go (eag) was first identified in Drosophila melanogaster based on the leg-shaking mutant phenotype [, ]. Later, the EAG (Ether-a-go-go) voltage-dependent potassium channel family was classified into 3 subfamilies: EAG, EAG-related gene (ERG), and EAG-like K+ channel (ELK). The mammalian EAG subfamily comprises of two members, termed EAG1 (KCNH1, KV10.1) and EAG2 (KCNH5, KV10.2) []. | Short Name: | EAG2 |
| GO Term | Gene Name |
|---|---|
| GO:0005249 | IPR030171 |
| GO:0042391 | IPR030171 |
| GO:0071805 | IPR030171 |
| GO:0005887 | IPR030171 |
| GO:0008076 | IPR030171 |
| GO Term | Gene Name |
|---|---|
| GO:0005249 | IPR030171 |
| GO:0042391 | IPR030171 |
| GO:0071805 | IPR030171 |
| GO:0005887 | IPR030171 |
| GO:0008076 | IPR030171 |
| DB identifier | Type | Name |
|---|---|---|
| IPR003949 | Family | Potassium channel, voltage-dependent, EAG |
