Protein Domain : IPR029539

Type:  Family Name:  Calpain-2
Description:  Calpain-2 (CAPN2, also known as m-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28 kDa) encoded by the gene Capn4 []. CAPN2 is required for proteolysis of cytoskeletal and focal adhesion proteins, such as FAK, paxillin, spectrin, and talin []. The cleavage of the cytoskeletal protein talin-1 (TLN1) by CAPN2 is critical for the disassembly of focal adhesions []. Short Name:  CAPN2
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10183:SF268

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004198 IPR029539
GO:0005509 IPR029539
GO:0006508 IPR029539
GO:0051493 IPR029539

4 Ontology Annotations

GO Term Gene Name
GO:0004198 IPR029539
GO:0005509 IPR029539
GO:0006508 IPR029539
GO:0051493 IPR029539

1 Parent Features

DB identifier Type Name
IPR022684 Family Peptidase C2, calpain family

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12843408
            24085852
            15302585
            18515801