3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016702 | IPR020833 |
| GO:0046872 | IPR020833 |
| GO:0055114 | IPR020833 |
| Type: | Binding_site | Name: | Lipoxygenase, iron binding site |
| Description: | Lipoxygenases () are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. In mammals a number of lipoxygenases isozymes are involved in the metabolism of prostaglandins and leukotrienes []. Sequence data is available for the following lipoxygenases: Plant lipoxygenases (). Plants express a variety of cytosolic isozymes as well as what seems to be a chloroplast isozyme [].Mammalian arachidonate 5-lipoxygenase ().Mammalian arachidonate 12-lipoxygenase ().Mammalian erythroid cell-specific 15-lipoxygenase ().The iron atom in lipoxygenases is bound by four ligands, three of which are histidine residues []. Six histidines are conserved in all lipoxygenase sequences, five of them are found clustered in a stretch of 40 amino acids. This region contains two of the three iron-ligands; the other histidines have been shown [] to be important for the activity of lipoxygenases.This entry represents a motif that contains the iron-binding sites. | Short Name: | LipOase_Fe_BS |
| GO Term | Gene Name |
|---|---|
| GO:0016702 | IPR020833 |
| GO:0046872 | IPR020833 |
| GO:0055114 | IPR020833 |
