Protein Domain : IPR022308

Type:  Family Name:  Synaptic vesicle protein SV2
Description:  SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor isoform (SV2C) that resemble transporter proteins. SV2B knockout mice are phenotypically normal while SV2A- and SV2A/SV2B double knockout mice exhibit severe seizures and die postnatally. Without SV2 proteins, presynaptic Ca2+accumulation during consecutive action potentials causes abnormal increases in neurotransmitter release that destabilise synaptic circuits and induce epilepsy []. Short Name:  SV2
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0 Child Features

2 Contains

DB identifier Type Name
IPR020846 Domain Major facilitator superfamily domain
IPR005829 Conserved_site Sugar transporter, conserved site

2 Cross Referencess

Identifier
PTHR24065
TIGR01299

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005215 IPR022308
GO:0006810 IPR022308
GO:0016020 IPR022308

3 Ontology Annotations

GO Term Gene Name
GO:0005215 IPR022308
GO:0006810 IPR022308
GO:0016020 IPR022308

1 Parent Features

DB identifier Type Name
IPR011701 Family Major facilitator superfamily

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10624962