| Type: | Domain | Name: | Arterivirus NSP4 peptidase domain |
| Description: | Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breedingindustries:Equine arteritis virus (EAV).Porcine reproductive and respiratory syndrome virus (PRRSV).Mice actate dehydrogenase-elevating virus.Simian hemorrhagic fever virus.The arterivirus replicase gene encodes two large precursor polyproteins that are processed by the viral main proteinase nonstructural protein 4 (NSP4). Thestructure of the enzyme reveals two chymotrypsin-like antiparallel beta- barrels and an extra C-terminal alpha/beta domain that may play a role inmediating protein-protein interactions. The N-terminal barrel consists of six beta-strands (A1 to F1), while the C-terminal barrel iscomposed of seven (A2 to G2). The core of both beta-barrels is comprised of conserved hydrophobic residues. The additional C-terminal domain consists oftwo pairs of short antiparallel beta-sheets and two alpha-helices. It interacts with the C-terminal barrel through an interface consisting ofconserved hydrophobic residues. A canonical catalytic triad that is composed of Ser, His, and Asp is located in the open cleft between the beta-barrelsdomain [, ]. The nsp4 proteinase domain is a member of peptidase family S32.The is entry represents the NSP4 proteinase domain. | Short Name: | Arterivirus_NSP4_peptidase |
