| Type: | Family | Name: | Transcription regulator DhaS |
| Description: | This entry represents a set of known and predicted TetR-like transcriptional regulators associated with operons encoding PEP-dependent dihydroxyacteone (Dha) kinases. The Lactococcus lactisDhaS protein has been shown to interact with the Dha-binding protein DhaQ to form a stable complex []. In the presence of Dha this complex activates transcription of the Dha kinase operon, leading to the utilisation of this substrate. Thus, unlike most TetR-like regulators, DhaS acts as an activator of gene expression rather than a repressor. The DhaS protein is composed of two monomers which fold into a wedge-shaped homodimer. Each monomer is composed of nine alpha helices and is divided into two domains: an N-terminal DNA-binding domain with a typical TetR fold, and a core domain involved in dimerisation. | Short Name: | Tscrpt_reg_DhaS |
