| Type: | Family | Name: | Proto-oncogene c-Rel |
| Description: | NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [].c-Rel plays a role in B-cell proliferation and survival. It is considered a proto-oncogene. c-Rel has been shown to be able to malignantly transform cultured cells, and amplifications of human c-rel are frequently seen in lymphomas []. | Short Name: | c-Rel |
| GO Term | Gene Name |
|---|---|
| GO:0003700 | IPR030505 |
| GO:0007249 | IPR030505 |
| GO:0045893 | IPR030505 |
| GO:0005634 | IPR030505 |
| GO:0005737 | IPR030505 |
| GO Term | Gene Name |
|---|---|
| GO:0003700 | IPR030505 |
| GO:0007249 | IPR030505 |
| GO:0045893 | IPR030505 |
| GO:0005634 | IPR030505 |
| GO:0005737 | IPR030505 |
