Protein Domain : IPR030497

Type:  Family Name:  Nuclear factor NF-kappa-B, p100 subunit
Description:  This entry represents the NF-kappaB subunit precursor p100, which can be processed to produce a 52 kDa protein (p52). p52 can form homodimers. It can also form heterodimers with different NF-kappaB family members, such as RelB, p65 and c-Rel [, ]. p100 inhibits c-Rel and reduces the expression of IL-23 in dendritic cells [].NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [].NF-kB1 and NF-kB2 are synthesised as large precursors, called p105 and p100, which undergo processing to generate the NF-kB subunits p50 and p52, respectively []. The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway, and involves selective degradation of their C-terminal regions containing ankyrin repeats []. Unlike RelA, RelB and c-Rel, p50 and p52 do not contain transactivation domains in their C-termini. Nevertheless, they play critical roles in modulating the specificity of NF-kB function []. Short Name:  NFkB_p100
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24169:SF19

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0006357 IPR030497
GO:0038061 IPR030497
GO:0005634 IPR030497
GO:0005737 IPR030497

4 Ontology Annotations

GO Term Gene Name
GO:0006357 IPR030497
GO:0038061 IPR030497
GO:0005634 IPR030497
GO:0005737 IPR030497

1 Parent Features

DB identifier Type Name
IPR000451 Family NF-kappa-B/Dorsal

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22302935
            22435556
            9597130
            10837071
            12360211
            25305492
            9315679
            16477006