Protein Domain : IPR017320

Type:  Family Name:  Histone deacetylase class II, eukaryotic
Description:  This group represents eukaryotic type class II histone deacetylases (), such as HDAC4, HDAC5, HDAC7 and HDAC9 [, , ]. These enzymes are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Histone acetyltransferases (HATs) cooperate with histone deacetylases to establish and maintain specific patterns of histone acetylation. Short Name:  Histone_deAcase_II_euk
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1 Child Features

DB identifier Type Name
IPR030703 Family Histone deacetylase 5

0 Contains

1 Cross References

Identifier
PIRSF037911

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004407 IPR017320
GO:0016568 IPR017320
GO:0000118 IPR017320

3 Ontology Annotations

GO Term Gene Name
GO:0004407 IPR017320
GO:0016568 IPR017320
GO:0000118 IPR017320

1 Parent Features

DB identifier Type Name
IPR000286 Family Histone deacetylase superfamily

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11804585
            12032081
            15923258