Protein Domain : IPR030681

Type:  Family Name:  Cholesterol 7-alpha-monooxygenase
Description:  Cholesterol 7-alpha-monooxygenase, also known as cytochrome P450 7A1, catalyses a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. It is the key enzyme that commits cholesterol to the neutral bile acid biosynthesis pathway, and is highly regulated []. Gene transcription of cholesterol 7alpha-hydroxylase is stimulated by glucose []. Short Name:  Cholesterol_7a_monooxygenase
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR24304:SF1
PIRSF500625

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0008123 IPR030681
GO:0006699 IPR030681
GO:0006707 IPR030681
GO:0042632 IPR030681
GO:0071333 IPR030681

5 Ontology Annotations

GO Term Gene Name
GO:0008123 IPR030681
GO:0006699 IPR030681
GO:0006707 IPR030681
GO:0042632 IPR030681
GO:0071333 IPR030681

1 Parent Features

DB identifier Type Name
IPR024204 Family Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            19965590
            14522988