| Type: | Family | Name: | Serpin B9/maspin |
| Description: | This family consists of serpin B5 (Maspin) and serpin B9. They are members of the serpin (SERine Protease INhibitor) family (MEROPS inhibitor family I4, clan ID). Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway []. Maspin is a non-inhibitory member of family [, ]. Maspin is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. Analysis of human breast cancer specimens has revealed that loss of maspin expression occurs most frequently in advanced cancers, supporting the hypothesis that maspin functions as a tumour suppressor []. | Short Name: | Serpin_B9/Maspin |
