| Type: | Family | Name: | Reverse gyrase |
| Description: | This entry represents reverse gyrases found in both bacteria and archaea. Reverse gyrase, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA []. Type I topoisomerases can be subdivided according to their structure and reaction mechanisms: type IA (bacterial and archaeal topoisomerase I, topoisomerase III and reverse gyrase) and type IB (eukaryotic topoisomerase I and topoisomerase V). Most of the Type I topoisomerases are ATP-independent and are responsible for relaxing positively and/or negatively supercoiled DNA. Reverse gyrase is a unique type IA topoisomerase in that it requires ATP and can introduce positive supercoils into DNA. | Short Name: | Reverse_gyrase |
| DB identifier | Type | Name |
|---|---|---|
| IPR011545 | Domain | DEAD/DEAH box helicase domain |
| IPR013824 | Domain | DNA topoisomerase, type IA, central region, subdomain 1 |
| IPR013497 | Domain | DNA topoisomerase, type IA, central |
| IPR003602 | Domain | DNA topoisomerase, type IA, DNA-binding domain |
| IPR003601 | Domain | DNA topoisomerase, type IA, domain 2 |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR005736 |
| GO:0003916 | IPR005736 |
| GO:0006265 | IPR005736 |
