3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005452 | IPR018241 |
| GO:0006820 | IPR018241 |
| GO:0016020 | IPR018241 |
| Type: | Conserved_site | Name: | Anion exchange, conserved site |
| Description: | Bicarbonate (HCO3-) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO3-transport modes. Anion exchanger proteins exchange HCO3-for Cl-in a reversible, electroneutral manner []. Na+/HCO3-co-transport proteins mediate the coupled movement of Na+and HCO3-across plasma membranes, often in an electrogenic manner []. Na-driven Cl-/HCO3-exchange and K+/HCO3-exchange activities have also been detected in certain cell types, although the molecular identities of the proteins responsible remain to be determined.Sequence analysis of the two families of HCO3-transporters that have been cloned to date (the anion exchangers and Na+/HCO3-co-transporters) reveals that they are homologous. This is not entirely unexpected, given that they both transport HCO3-and are inhibited by a class of pharmacological agents called disulphonic stilbenes []. They share around ~25-30% sequence identity, which is distributed along their entire sequence length, and have similar predicted membrane topologies, suggesting they have ~10 transmembrane (TM) domains.Anion exchange proteins participate in pH and cell volume regulation. They are glycosylated, plasma-membrane transport proteins thatexchange hydrogen carbonate (HCO3-) for chloride (Cl-) in a reversible, electroneutral manner [, ]. To date three anion exchanger isoforms havebeen identified (AE1-3), AE1 being the previously-characterised erythrocyte band 3 protein. They share a predicted topology of 12-14 transmembrane (TM)domains, but have differing distribution patterns and cellular localisation. The best characterised isoform, AE1, is known to be the most abundantmembrane protein in mature erythrocytes. It has a molecular mass of ~95kDa and consists of two major domains. The N-terminal 390 residues form a water-soluble, highly elongated domain that serves as an attachment site for the binding of the membrane skeleton and other cytoplasmic proteins. Theremainder of the protein is a 55kDa hydrophobic domain that is responsible for catalysing anion exchange. The function of the analogous domains of AE2and AE3 remains to be determined [].Naturally-occurring mutations have been characterised in the AE1 gene, which give rise to forms of several human diseases: included are spherocytosis,affecting red blood cells, and familial distal renal tubular acidosis, a kidney disease associated with the formation of kidney stones []. | Short Name: | Anion_exchange_CS |
| GO Term | Gene Name |
|---|---|
| GO:0005452 | IPR018241 |
| GO:0006820 | IPR018241 |
| GO:0016020 | IPR018241 |
