Protein Domain : IPR005963

Type:  Family Name:  Tryptophan 5-monooxygenase
Description:  Tryptophan 5-monooxygenase () is a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. It is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system and catalyzes the first step of the synthesis of melatonin in the pineal gland [].L-tryptophan + tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + dihydropteridine + H2O Short Name:  Trp_5_mOase
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0 Child Features

3 Contains

DB identifier Type Name
IPR002912 Domain ACT domain
IPR019774 Domain Aromatic amino acid hydroxylase, C-terminal
IPR018301 Binding_site Aromatic amino acid hydroxylase, iron/copper binding site

1 Cross References

Identifier
TIGR01270

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004510 IPR005963
GO:0042427 IPR005963
GO:0055114 IPR005963

3 Ontology Annotations

GO Term Gene Name
GO:0004510 IPR005963
GO:0042427 IPR005963
GO:0055114 IPR005963

1 Parent Features

DB identifier Type Name
IPR019773 Family Tyrosine 3-monooxygenase-like

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11472242