Protein Domain : IPR017660

Type:  Family Name:  Oxalyl-CoA decarboxylase
Description:  Oxalate accumulation from amino-acid catabolism is toxic and leads to acute disorders in mammals. Gut microflora are therefore pivotal in maintaining a safe intestinal oxalate balance through oxalate degradation. A number of bacteria, including Oxalobacter formigenesfrom the human gut, can carry out oxalate degradation via a two-step process []:Formyl-CoA transferase (frc; ) catalyses the transfer of the CoA moiety from formyl-CoA to oxalate.Oxalate decarboxylase (oxc; ) catalyses the formation of formyl-CoA and carbon dioxide from oxalyl-CoA.This entry represents the enzyme oxalyl-CoA decarboxylase (), which binds one metal ion (usually magnesium) and one thiamine pyrophosphate (TPP) per subunit as cofactors []. Short Name:  Oxalyl-CoA_decarboxylase
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0 Child Features

3 Contains

DB identifier Type Name
IPR011766 Domain Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR012000 Domain Thiamine pyrophosphate enzyme, central domain
IPR012001 Domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain

1 Cross References

Identifier
TIGR03254

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008949 IPR017660
GO:0030976 IPR017660
GO:0046872 IPR017660
GO:0033611 IPR017660

4 Ontology Annotations

GO Term Gene Name
GO:0008949 IPR017660
GO:0030976 IPR017660
GO:0046872 IPR017660
GO:0033611 IPR017660

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16517636
            15345383