Protein Domain : IPR030534

Type:  Family Name:  Double C2-like domain-containing protein beta
Description:  Doc2b (double C2-like domain-containing protein beta) is a member of the double C2 domain protein family, containing two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ]. Short Name:  Doc2b
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10024:SF173

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0005509 IPR030534
GO:0005544 IPR030534
GO:0031340 IPR030534
GO:0032024 IPR030534
GO:0045956 IPR030534
GO:0048791 IPR030534

6 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR030534
GO:0005544 IPR030534
GO:0031340 IPR030534
GO:0032024 IPR030534
GO:0045956 IPR030534
GO:0048791 IPR030534

1 Parent Features

DB identifier Type Name
IPR014638 Family Double C2 protein, alpha/beta/gamma

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22698913
            8902635
            25005332
            20150444
            19033398