| Type: | Family | Name: | Lon protease, bacterial |
| Description: | Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress []. In pathogenic bacteria, it is required for the expression of virulence genes that promote cell infection [].Lon (La) protease was the first ATP-dependent protease to be purified from E. coli [, , , ]. The enzyme is a homotetramer of 87kDa subunits, with one proteolytic and one ATP-binding site per monomer, making it structurally less complex than other known ATP-dependent proteases []. Despite this relative structural simplicity, Lon recognises its substrates directly, without delegating the task of substrate recognition to other enzymes []. This entry represents a subfamily of bacterial lon proteases. | Short Name: | Lon_bac |
| GO Term | Gene Name |
|---|---|
| GO:0004176 | IPR027543 |
| GO:0004252 | IPR027543 |
| GO:0005524 | IPR027543 |
| GO:0043565 | IPR027543 |
| GO:0006508 | IPR027543 |
| GO Term | Gene Name |
|---|---|
| GO:0004176 | IPR027543 |
| GO:0004252 | IPR027543 |
| GO:0005524 | IPR027543 |
| GO:0043565 | IPR027543 |
| GO:0006508 | IPR027543 |
