Protein Domain : IPR022429

Type:  Family Name:  Alanine-tRNA ligase, archaea
Description:  Alanine-tRNA ligase (also known as alanyl-tRNA synthetase) () is an alpha4 tetramer that belongs to class IIc. Alanine-tRNA ligase catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). It also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.This family of alanine-tRNA ligases is limited to the archaea. The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Ala-tRNA_lgiase_arc
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0 Child Features

6 Contains

DB identifier Type Name
IPR003156 Domain DHHA1 domain
IPR018162 Domain Alanine-tRNA ligase, class IIc, anti-codon-binding domain
IPR012947 Domain Threonyl/alanyl tRNA synthetase, SAD
IPR018163 Domain Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018165 Domain Alanyl-tRNA synthetase, class IIc, core domain
IPR018164 Domain Alanyl-tRNA synthetase, class IIc, N-terminal

2 Cross Referencess

Identifier
TIGR03683
MF_00036_A

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0000166 IPR022429
GO:0006419 IPR022429
GO:0005737 IPR022429

3 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR022429
GO:0006419 IPR022429
GO:0005737 IPR022429

1 Parent Features

DB identifier Type Name
IPR002318 Family Alanine-tRNA ligase, class IIc

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971