1 Child Features
| DB identifier | Type | Name |
|---|---|---|
| IPR014098 | Family | Phenylphosphate carboxylase, delta subunit |
| Type: | Family | Name: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase |
| Description: | This entry is a part of the haloacid dehalogenase (HAD) superfamily of hydrolases from beta, gamma and epsilon proteobacteria, Aquifex, Fusobacterium, Porphyromonas and Methanosarcina. All characterised members of the HAD-superfamily hydrolase, subfamily IIIA and most characterised members of the HAD superfamily are phosphatases. HAD superfamily phosphatases contain active site residues in several conserved catalytic motifs [], all of which are found conserved in this family.Lipopolysaccharides of Gram-negative bacteria consist of a heteropolysaccharide component (O-antigen) and a hydrophobic component (lipid A). Linking the two portions is 3-Deoxy-D-manno-octulosonate (KDO), an 8-carbon sugar. Biosynthesis of KDO linked to lipid A proceeds via five steps, one of which involves removal of a phosphate from KDO 8-P via the action of KDO 8-P phosphatase () []. One member of this family, the YrbI protein from Haemophilus influenzaehas been cloned, expressed, purified and found to be an active phosphatase. Furthermore, its crystal structure has been determined [].The sequence from Methanosarcina acetivorans, , is distinctive in that it is linked to an N-terminal cytidylyltransferase domain () and is annotated as acylneuraminate cytidylyltransferase. This may give some clue as the function of these phosphatases. Several eukaryotic sequences are also closely related to this family; one such sequence is the CMP-N-acetylneuraminic acid synthetase from mouse, but in this case as in the others the phosphatase domain is clearly inactive as many of the active site residues are not conserved. | Short Name: | KDO_8-P_phosphatase |
| DB identifier | Type | Name |
|---|---|---|
| IPR014098 | Family | Phenylphosphate carboxylase, delta subunit |
