Protein Domain : IPR004791

Type:  Family Name:  UvrABC system, subunit C
Description:  The UvrABC repair system catalyses the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage [].This family defines the C subunit (the DNA repair enzyme UvrC) which interacts with the UvrA/UvrB complex to excise UV-damaged nucleotide segments. The C subunit is found only in the bacteria and archaea. Short Name:  UvrC
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0 Child Features

3 Contains

DB identifier Type Name
IPR010994 Domain RuvA domain 2-like
IPR001162 Domain UvrC family homology region
IPR003583 Domain Helix-hairpin-helix DNA-binding motif, class 1

2 Cross Referencess

Identifier
TIGR00194
MF_00203

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0009381 IPR004791
GO:0006281 IPR004791
GO:0005737 IPR004791
GO:0009380 IPR004791

4 Ontology Annotations

GO Term Gene Name
GO:0009381 IPR004791
GO:0006281 IPR004791
GO:0005737 IPR004791
GO:0009380 IPR004791

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12145219