Protein Domain : IPR004743

Type:  Family Name:  Monocarboxylate transporter
Description:  Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities []. MCT1-4 have been linked to cancer maintenance and aggressiveness []. Short Name:  MCT
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5 Child Features

DB identifier Type Name
IPR030757 Family Monocarboxylate transporter 1
IPR030759 Family Monocarboxylate transporter 3
IPR030760 Family Monocarboxylate transporter 6
IPR027178 Family Monocarboxylate transporter 2
IPR030756 Family Monocarboxylate transporter 4

0 Contains

1 Cross References

Identifier
TIGR00892

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008028 IPR004743
GO:0015718 IPR004743
GO:0016021 IPR004743

3 Ontology Annotations

GO Term Gene Name
GO:0008028 IPR004743
GO:0015718 IPR004743
GO:0016021 IPR004743

1 Parent Features

DB identifier Type Name
IPR011701 Family Major facilitator superfamily

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9425115
            22131303
            22407107