| Type: | Family | Name: | Abl interactor 1 |
| Description: | Abl interactor 1 (ABI1) belongs to the ABI family and plays an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. It participates in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [, , ]. ABI1 promotes tyrosine phosphorylation of mammalian enabled (Mena) by c-Abl kinase []. It is essential for WAVE2 complex integrity and embryonic survival in mice []. ABI1 and the p85 regulatory subunit of PI-3 kinase may be the link between actin cytoskeleton remodelling and growth receptor signalling []. | Short Name: | ABI1 |
