Protein Domain : IPR004418

Type:  Family Name:  Homoaconitase, mitochondrial
Description:  Homoaconitase (cis-homoaconitase; ) catalyses the dehydration of cis-homoaconitate to homoisocitric acid. It is an enzyme from the alpha-aminoadipate pathway of lysine biosynthesis, and has been identified in higher fungi and several archaea and one thermophilic species of bacteria, Thermus thermophilus[]. Like aconitase, this enzyme binds a [4Fe-4S]-cluster, and it has a similar domain architecture to aconitase and isopropylmalate isomerase family proteins, although it catalyses a different reaction []. Homoaconitase is found in the mitochondria of certain fungi. Short Name:  Homoaconitase_mito
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0 Child Features

5 Contains

DB identifier Type Name
IPR015931 Domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
IPR000573 Domain Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
IPR001030 Domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
IPR015932 Domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
IPR018136 Binding_site Aconitase family, 4Fe-4S cluster binding site

2 Cross Referencess

Identifier
PTHR11670:SF8
TIGR00139

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004409 IPR004418
GO:0051539 IPR004418
GO:0009085 IPR004418

3 Ontology Annotations

GO Term Gene Name
GO:0004409 IPR004418
GO:0051539 IPR004418
GO:0009085 IPR004418

1 Parent Features

DB identifier Type Name
IPR015937 Family Aconitase/isopropylmalate dehydratase

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16524361
            9541534