Protein Domain : IPR028546

Type:  Family Name:  Klotho
Description:  Klotho (named after a Greek goddess Klotho who spins the thread of life) was first identified as a gene disrupted in a mouse strain that inherited a syndrome resembling human ageing in an autosomal recessive manner []. Klotho is related to glycoside hydrolase and have two forms, membrane Klotho and secreted Klotho. Membrane Klotho forms a complex with fibroblast growth factor receptors and functions as an co-receptor for fibroblast growth factor 23, while secreted Klotho functions as a humoral factor that regulates activity of multiple glycoproteins on the cell surface []. The secreted Klotho may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signalling []. Overexpression of Klotho in mice can extend life span [].Mutations in human Klotho cause the tumoral calcinosis, hyperphosphatemic, familial (HFTC): a severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues []. Short Name:  Klotho
Paste the following link

0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10353:SF10

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0004871 IPR028546
GO:0007568 IPR028546
GO:0008286 IPR028546
GO:0008543 IPR028546
GO:0005615 IPR028546
GO:0016021 IPR028546

6 Ontology Annotations

GO Term Gene Name
GO:0004871 IPR028546
GO:0007568 IPR028546
GO:0008286 IPR028546
GO:0008543 IPR028546
GO:0005615 IPR028546
GO:0016021 IPR028546

1 Parent Features

DB identifier Type Name
IPR001360 Family Glycoside hydrolase, family 1

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9363890
            16123266
            19730882
            17710231