Protein Domain : IPR004503

Type:  Family Name:  Serine-tRNA ligase, class IIa, archaea
Description:  Serine-tRNA ligase () exists as monomer and belongs to class IIa [].The serine-tRNA ligases from a few of the archaea that belong to this group are different from the set of mutually more closely related serine-tRNA ligases from eubacteria, eukaryotes, and other archaea ().The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Ser-tRNA-ligase_IIa_arc
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0 Child Features

1 Contains

DB identifier Type Name
IPR002314 Domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

2 Cross Referencess

Identifier
TIGR00415
MF_01278

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0000166 IPR004503
GO:0004828 IPR004503
GO:0005524 IPR004503
GO:0006434 IPR004503
GO:0005737 IPR004503

5 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR004503
GO:0004828 IPR004503
GO:0005524 IPR004503
GO:0006434 IPR004503
GO:0005737 IPR004503

0 Parent Features

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971
            7540217