1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR016243 | Family | Tyrosine-protein kinase, CSF-1/PDGF receptor family |
| Type: | Family | Name: | Platelet-derived growth factor receptor alpha |
| Description: | Platelet-derived growth factor (PDGF) is a growth factor that plays a significant role in cell proliferation and embryonic develpment. It is regulated through the platelet-derived growth factor receptor (PDGFR), a tyrosine kinase (RTK) []. There are two types of PDGFR: alpha and beta. This entry represents the alpha type PDGFR (PDGFRA). In human, there are four genes expressing PDGF chains: PDGF-A, B, C and D. They can form isoforms with each other, such as PDGF-AA, AB, BB, CC and DD [, ]. PDGF isoforms bind twodistinct receptors, PDGF-alpha and -beta, and this mechanism induces receptor autophosphorylation and activates signal transduction []. PDGFR alpha acts as a receptor for homodimeric PDGF-AA, PDGF-BB and PDGF-CC and for heterodimers formed by PDGF-AB [, ]. The activities of the PDGFs have been extensively studied at the molecular and cellular level and in in vivo model systems [, , , , , , , , , ]. A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome [, ]. Defects in PDGFRA are a cause of gastrointestinal stromal tumor [, ]. | Short Name: | PDGFRA |
| DB identifier | Type | Name |
|---|---|---|
| IPR016243 | Family | Tyrosine-protein kinase, CSF-1/PDGF receptor family |
