Protein Domain : IPR027263

Type:  Family Name:  Mast/stem cell growth factor receptor
Description:  Mast/stem cell growth factor receptor (Kit) is a receptor protein-tyrosine kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Kit consists of an extracellular domain, a transmembrane segment, a juxtamembrane segment, and a protein kinase domain that contains an insert of about 80 amino acid residues. Binding of stem cell factor to Kit results in receptor dimerization and activation of protein kinase activity [, , , , , , , , , , ]. Short Name:  SCGF_receptor
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0 Child Features

0 Contains

1 Cross References

Identifier
PIRSF500951

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004716 IPR027263
GO:0019955 IPR027263
GO:0038093 IPR027263
GO:0038109 IPR027263

4 Ontology Annotations

GO Term Gene Name
GO:0004716 IPR027263
GO:0019955 IPR027263
GO:0038093 IPR027263
GO:0038109 IPR027263

1 Parent Features

DB identifier Type Name
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family

0 Proteins

11 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16129412
            7520444
            9528781
            10397721
            12444928
            12878163
            12511554
            17904548
            19265199
            21640708
            21135090