| Type: | Conserved_site | Name: | Carboxylesterase type B, conserved site |
| Description: | Higher eukaryotes have many distinct esterases. Among the different types are those which act on carboxylic esters (). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis ofdifferential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates [, , ] that the majority are evolutionary related. As is the case for lipases and serine proteases, the catalytic apparatus ofesterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This entry represents a well conserved site located in the N-terminal section, which contains a cysteine involved in a disulphide bond. Human esterase-D, also a type-B carboxylesterase, does not seem to be evolutionary related. | Short Name: | Carboxylesterase_B_CS |
