Protein Domain : IPR020853

Type:  Family Name:  Peptide chain release factor 2, bacterial
Description:  Peptide chain release factors (RFs) are required for the termination of protein biosynthesis []. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RF activity. In prokaryotes there are two class I RFs that act in a codon specific manner []: RF-1 (gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB), which is represented by this entry, mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown [] to be part of a larger family. Short Name:  Peptide_chain_release_fac2_bac
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0 Child Features

2 Contains

DB identifier Type Name
IPR005139 Domain Peptide chain release factor
IPR000352 Domain Peptide chain release factor class I/class II

1 Cross References

Identifier
MF_00094

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016149 IPR020853
GO:0006415 IPR020853
GO:0005737 IPR020853

3 Ontology Annotations

GO Term Gene Name
GO:0016149 IPR020853
GO:0006415 IPR020853
GO:0005737 IPR020853

1 Parent Features

DB identifier Type Name
IPR004374 Family Peptide chain release factor 2

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2215213
            1408743
            8821264