Protein Domain : IPR028339

Type:  Family Name:  Folate transporter 1
Description:  Folate transporter 1 (RFC, also known as SLC19A1) belongs to the reduced folate carrier (RFC) transporter family (). It is a transporter for the intake of folate, reduced folates and methotrexate []. It has a function in folate homeostasis and thus in preventing diseases such as neural tube defects and other birth defects []. Mutations in the SLC19A1 gene have been found to be correlated with various cancers and with variable response to methotrexate and related compounds for rheumatoid arthritis and cancer []. Short Name:  RFC
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR10686:SF12
PIRSF500793

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0008517 IPR028339
GO:0015350 IPR028339
GO:0015884 IPR028339
GO:0051958 IPR028339
GO:0005887 IPR028339

5 Ontology Annotations

GO Term Gene Name
GO:0008517 IPR028339
GO:0015350 IPR028339
GO:0015884 IPR028339
GO:0051958 IPR028339
GO:0005887 IPR028339

1 Parent Features

DB identifier Type Name
IPR002666 Family Reduced folate carrier

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7641195
            20811316
            20683905