| Type: | Family | Name: | Neuromodulin (GAP-43) |
| Description: | Neuromodulin is a component of the motile growth cones. It is membrane protein whose expression iswidely correlated with successful axon elongation []. It is a crucialcomponent of an effective regeneration response in the nervous system [].Although its function is uncertain, the N-terminal region is well conserved and contains both a calmodulin binding domain, and sites foracylation, membrane attachment and protein kinase C phosphorylation. Structure predictions suggest that the C-terminal region may exist as an extended, negatively-charged rod with somesimilarity to the side arms of neurofilaments, indicating that the biological role of neuromodulin may depend on its ability to form adynamic membrane-cytoplasm-calmodulin complex []. | Short Name: | Neuromodulin |
