Protein Domain : IPR021187

Type:  Family Name:  Band 4.1 protein
Description:  Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating physical properties of the membrane, such as mechanical stability and de-formability, by stabilising spectrin-actin interactions [, , ]. The protein has been shown to associate with the nuclear mitotic apparatus, the contractile apparatus and tight junctions. Defects in this protein can cause elliptocytosis type 1 and hereditary pyropoikilocytosis.Note: Band 4.1 and Band 7 () proteins refer to human erythrocyte membrane proteins separated by SDS polyacrylamide gels and stained with coomassie blue []. Short Name:  Band_41_protein
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0 Child Features

11 Contains

DB identifier Type Name
IPR014352 Domain FERM/acyl-CoA-binding protein, 3-helical bundle
IPR011993 Domain Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
IPR019748 Domain FERM central domain
IPR018979 Domain FERM, N-terminal
IPR000299 Domain FERM domain
IPR019749 Domain Band 4.1 domain
IPR019747 Conserved_site FERM conserved site
IPR018980 Domain FERM, C-terminal PH-like domain
IPR014847 Domain FERM adjacent (FA)
IPR007477 Domain SAB domain
IPR008379 Domain Band 4.1, C-terminal

1 Cross References

Identifier
PTHR23280:SF12

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR000798 Family Ezrin/radixin/moesin-like

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            4326772
            11003675
            11017195
            1647028