Protein Domain : IPR028297

Type:  Family Name:  Wiskott-Aldrich syndrome protein homologue, fungal
Description:  This entry represent the fungal homologue of the WASP (Wiscott-Aldrich syndrome) protein, including Wsp1 from Schizosaccharomyces pombe and Las17 from Saccharomyces cerevisiae. Similar to mammalian WASP proteins, Wsp1 and Las17 also has a role in regulating actin assembly [, ]. In Saccharomyces cerevisiae, Las17 is the primary activator of Arp2/3-driven actin nucleation and is required for membrane invagination during endocytosis []. Las17 can also nucleate actin filaments independently of Arp2/3 through its polyproline domain []. Short Name:  Wsp1/Las17_fungal
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR23202:SF2

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003779 IPR028297
GO:0006897 IPR028297
GO:0007015 IPR028297
GO:2000601 IPR028297
GO:0030479 IPR028297

5 Ontology Annotations

GO Term Gene Name
GO:0003779 IPR028297
GO:0006897 IPR028297
GO:0007015 IPR028297
GO:2000601 IPR028297
GO:0030479 IPR028297

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10512884
            11076964
            23290554