3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0019901 | IPR015453 |
| GO:0000079 | IPR015453 |
| GO:0010389 | IPR015453 |
| Type: | Family | Name: | Cyclin A, chordates |
| Description: | Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2(Herpesvirus saimiri) and Human herpesvirus 8(HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This entry represents chordate cyclin A, which can activate two different cyclin-dependent kinases, Cdk1 and Cdk2, and functions in both S phase and mitosis. Synthesis of cyclin A begins as cells approach the G1-S transition and it is abruptly destroyed before metaphase []. The sequence elements in CycA that are responsible for its degradation are located in the N-terminal part of the molecule and consist of a KEN box, a D box and another yet-uncharacterised destruction element C-terminal to the D box [].Cyclin A is required for DNA synthesis. Formation and activation of the pre-replication complex requires coordinate actions of G1 and S phase cyclin-dependent kinases, cyclin E-Cdk2 and cyclin A-Cdk2 respectively []. | Short Name: | Cyclin_A_chordates |
| GO Term | Gene Name |
|---|---|
| GO:0019901 | IPR015453 |
| GO:0000079 | IPR015453 |
| GO:0010389 | IPR015453 |
