Protein Domain : IPR015452

Type:  Family Name:  Cyclin B3, G2/mitotic-specific
Description:  Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groupsof cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2(Herpesvirus saimiri) and Human herpesvirus 8(HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Cyclin B3 is conserved from Caenorhabditis elegansto Homo sapiens(Human) and has an undefined meiotic function in female, but not male Drosophila melanogaster(Fruit fly). Cyclin B3 interacts with cdk2, is localised to the nucleus, and is degraded during anaphase entry after the degradation of cyclin B1. Degradation is dependent on sequences conserved in a destruction box motif. Over expression of nondegradable cyclin B3 blocks the mitotic cell cycle in late anaphase, and at higher doses it can interfere with progression through G(1) and entry into S phase. The expression pattern of mammalian cyclin B3 suggests that it may be important for events occurring in early meiotic prophase I [].In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. The assignment of cyclin B3 to the B-type subfamily is based on cDNA-derived sequence and its pattern of expression in synchronised cells, both suggesting a distant relationship to other B-type cyclins. Interestingly, however, cyclin B3 also displays properties that resemble those of A- rather than B-type cyclins []. Short Name:  Cyclin_B3

0 Child Features

3 Contains

DB identifier Type Name
IPR013763 Domain Cyclin-like
IPR006671 Domain Cyclin, N-terminal
IPR004367 Domain Cyclin, C-terminal domain

1 Cross References

Identifier
PTHR10177:SF22

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0019901 IPR015452
GO:0000079 IPR015452
GO:0010389 IPR015452

3 Ontology Annotations

GO Term Gene Name
GO:0019901 IPR015452
GO:0000079 IPR015452
GO:0010389 IPR015452

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11056549
            12910258
            12185076
            8313904