Protein Domain : IPR001006

Type:  Family Name:  Procollagen-lysine 5-dioxygenase
Description:  Synonym(s): Lysine hydroxylase, Lysyl hydroxylase, etc Procollagen-lysine 5-dioxygenase () catalyses the hydroxylation of lysine residues in X-Lys-Gly sequences in collagens. The resulting hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks. At least three isoforms are known in vertebrates.The enzyme requires iron, 2-oxoglutarate, oxygen and ascorbate for its activity []. Three residues, two histidine and an aspartate, are involved in the binding of the iron ion. Short Name:  Procol_lys_dOase
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0 Child Features

1 Contains

DB identifier Type Name
IPR006620 Domain Prolyl 4-hydroxylase, alpha subunit

1 Cross References

Identifier
PS01325

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008475 IPR001006
GO:0055114 IPR001006
GO:0005783 IPR001006

3 Ontology Annotations

GO Term Gene Name
GO:0008475 IPR001006
GO:0055114 IPR001006
GO:0005783 IPR001006

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8621606