| Type: | Family | Name: | Alternate F1F0 ATPase, F1 subunit alpha |
| Description: | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [, ]. The different types include:F-ATPases (F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases), which are primarily found in eukaryotic and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane []. They are also found in bacteria [].A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [, ].P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.A small number of taxonomically diverse prokaryotic species, including Methanosarcina barkeri, have what appears to be a second ATP synthase, in addition to the normal F1F0 ATPase in bacteria and A1A0 ATPase in archaea []. These enzymes use ion gradients to synthesize ATP, and in principle may run in either direction. This entry represents the F1 alpha subunit of this apparent second ATP synthase. | Short Name: | Alt_ATPase_F1_asu |
| DB identifier | Type | Name |
|---|---|---|
| IPR000194 | Domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain |
| IPR000793 | Domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal |
| IPR004100 | Domain | ATPase, F1 complex alpha/beta subunit, N-terminal domain |
| IPR020003 | Active_site | ATPase, alpha/beta subunit, nucleotide-binding domain, active site |
| GO Term | Gene Name |
|---|---|
| GO:0016820 | IPR017710 |
| GO:0015986 | IPR017710 |
| GO:0045261 | IPR017710 |
